Journal: Pharmaceutics

Article Title: Leveraging Numerical Simulation Technology to Advance Drug Preparation: A Comprehensive Review of Application Scenarios and Cases

doi: 10.3390/pharmaceutics16101304

Figure Lengend Snippet: Summary of the literature related to numerical simulation mechanism modeling of microneedles.

Article Snippet: , - , COMSOL , The formulation and evaluation of a chitosan microneedle patch for the transdermal delivery of meloxicam to manage pain in cattle , Simulation of transdermal drug delivery process by microneedle patch system , Chitosan microneedle patch , [ ] .

Techniques: Permeability, Diffusion-based Assay, Drug Transport Assay, Injection, In Vitro, Formulation, Construct, In Vivo, Dissolution, Computed Tomography, Concentration Assay

Journal: Pharmaceutics

Article Title: Leveraging Numerical Simulation Technology to Advance Drug Preparation: A Comprehensive Review of Application Scenarios and Cases

doi: 10.3390/pharmaceutics16101304

Figure Lengend Snippet: COMSOL simulation demonstrated that the transdermal drug delivery increases in function to the increment of the number of microneedles on the surface patch and percentage of penetration per microneedle. Effect of penetration % of one microneedle into the skin. ( A ) Insertion of one microneedle into the skin. ( i ) 25% insertion, ( ii ) 50% insertion, ( iii ) 75% insertion, and ( iv ) 100% insertion. ( B ) Transdermal drug delivery versus % of penetration of one microneedle into the skin. Effect of the number of microneedles. ( C ) Concentration profile of microneedles into the skin. ( i ) one microneedle, ( ii ) thirty microneedles. ( D ) The tendency of transdermal drug delivery versus the number of microneedles into the skin, empirical eq. ( E ) Transdermal drug delivery versus the number of microneedle patches penetrating the skin .

Article Snippet: , - , COMSOL , The formulation and evaluation of a chitosan microneedle patch for the transdermal delivery of meloxicam to manage pain in cattle , Simulation of transdermal drug delivery process by microneedle patch system , Chitosan microneedle patch , [ ] .

Techniques: Concentration Assay

Journal: Polymers

Article Title: Microneedles in Action: Microneedling and Microneedles-Assisted Transdermal Delivery

doi: 10.3390/polym14081608

Figure Lengend Snippet: Marketed microneedle-based transdermal products 1 .

Article Snippet: Micro-Trans ® , Valeritas Inc., Bridgewater, NJ, USA , Microneedle Patch , It delivers the drug into the dermis without limitations of drug size, structure, charge, or the patient’s skin characteristics. , .

Techniques: Vaccines, Microinjection, Injection

Journal: Polymers

Article Title: Microneedles in Action: Microneedling and Microneedles-Assisted Transdermal Delivery

doi: 10.3390/polym14081608

Figure Lengend Snippet: Schematic of the microneedle-assisted transdermal delivery of aPD1 for skin cancer treatment. ( a ) Schematic of the aPD1 delivered by an MN patch loaded with physiologically self-dissociated NPs. With GOx/CAT enzymatic system immobilized inside the NPs by double-emulsion method, the enzyme-mediated conversion of blood glucose to gluconic acid promotes the sustained dissociation of NPs, subsequently leading to the release of aPD1. ( b ) The blockade of PD-1 by aPD1 activates the immune system to destroy skin cancer cells. Reproduced from .

Article Snippet: Micro-Trans ® , Valeritas Inc., Bridgewater, NJ, USA , Microneedle Patch , It delivers the drug into the dermis without limitations of drug size, structure, charge, or the patient’s skin characteristics. , .

Techniques: Double Emulsion

Journal: Pharmaceutics

Article Title: Potential of Microneedle Systems for COVID-19 Vaccination: Current Trends and Challenges

doi: 10.3390/pharmaceutics14051066

Figure Lengend Snippet: Comparison of syringe and MN vaccination.

Article Snippet: 10. , Vaxxas (Nanopatch TM ) , Coated microneedles array patch , Influenza, COVID-19.

Techniques: Comparison

Journal: Pharmaceutics

Article Title: Potential of Microneedle Systems for COVID-19 Vaccination: Current Trends and Challenges

doi: 10.3390/pharmaceutics14051066

Figure Lengend Snippet: dMN manufacturing methods (taken from ) Micromolding with a polydimethylsiloxane (PDMS) mold is the most prevalent method for producing dMNs. Drawing lithography operates by extending two-dimensional polymeric material into a three-dimensional shape. Longitudinal extension of molten polymer by pillaring higher moving plate. In soft lithography , dMNs are produced by (A) heating a polymer sheet and a mold with microcavities. (B) The filled mold is then heated and placed on a flexible, water-soluble substrate. After mold detachment, a dMN patch remains on the substrate. Droplet-born air blowing (DAB) applies a (A) polymer solution and (B) a drug solution to two plates. (C) The upper plate is lowered until the droplets meet, (D)then withdrawn a distance equal to the two dMN lengths of the lower and top plates. (E) Drying the polymer solutions results in a dMN patch on each plate. (F) In addition, fabrication at moderate temperatures (4–25 degrees Celsius) minimizes medication and polymer waste. dMN on an electrospun pillar array (DEPA) is a variant of DAB. (A) The flat plate is replaced with a columnar array covered in a fibrous layer. (B) A PDMS slab is then utilized to draw and stretch polymer formulation droplets, resulting in microneedles. (C) Finally, the movement of air dries off the elongated droplets to form dissolving microneedles.

Article Snippet: 10. , Vaxxas (Nanopatch TM ) , Coated microneedles array patch , Influenza, COVID-19.

Techniques: Polymer, Produced, Variant Assay, Formulation

Journal: Pharmaceutics

Article Title: Potential of Microneedle Systems for COVID-19 Vaccination: Current Trends and Challenges

doi: 10.3390/pharmaceutics14051066

Figure Lengend Snippet: Fabrication of novel dissolving MNAs with undercut microneedles. ( A ) Finished items according to each stage of the production plan outlined. The scale bar measures 10 mm. ( B – I ). Optical stereomicroscopy was used to verify the geometric quality of the produced MNAs. The scale bars are 250 m in length. ( B ) Three-dimensional direct laser writing was used to generate the master MNA. ( C ) A two-stage micromolding approach was used to generate a replica of the master MNA (elastomer molding combined with UV-curable micromolding). ( D ) Wells formed like microneedles in an MNA manufacturing mold. ( E ) Dissolving CMC/trehalose MNA in the final stage, including a multicomponent vaccine (OVA + Poly(I:C)). ( F ) A closer look at a single undercut microneedle on the 3D-printed master MNA (as in B). ( G ) Magnification of an individual undercut microneedle on a master MNA replica at higher magnification (as in C ). ( H ) Dissolving PVP/PVA microneedle tip filled with Alexa680-labeled OVA at the end. ( I ) A final dissolving CMC/trehalose microneedle tip filled with doxorubicin, a red-colored, chemotherapeutic, small-molecule medication, is shown. (Taken from ).

Article Snippet: 10. , Vaxxas (Nanopatch TM ) , Coated microneedles array patch , Influenza, COVID-19.

Techniques: Produced, Labeling

Journal: Medicines

Article Title: Beyond the Needle: Innovative Microneedle-Based Transdermal Vaccination

doi: 10.3390/medicines12010004

Figure Lengend Snippet: History of microneedle development. Image reprinted with permission , 2023, Pharmaceutics .

Article Snippet: Vaxxas (Nanopatch TM ) , Coated microneedle array patch , Influenza, COVID-19.

Techniques:

Journal: Pharmaceutics

Article Title: Microneedles for Efficient and Precise Drug Delivery in Cancer Therapy

doi: 10.3390/pharmaceutics15030744

Figure Lengend Snippet: Common examples of commercially available various types of microneedle patches for various applications.

Article Snippet: Nanoject ® ; Debiotech, Lausanne, Switzerland , Dissolvable peptide microneedle patch , Intradermal and hypodermic drug delivery and for interstitial fluid diagnostics , [ ] .

Techniques:

Journal: Pharmaceutics

Article Title: Microneedles for Efficient and Precise Drug Delivery in Cancer Therapy

doi: 10.3390/pharmaceutics15030744

Figure Lengend Snippet: Advantages and limitations of different types of microneedles (solid, hollow, coated and dissolving) for use in cancer therapy (modified from [ 27 , 28 ]).

Article Snippet: Nanoject ® ; Debiotech, Lausanne, Switzerland , Dissolvable peptide microneedle patch , Intradermal and hypodermic drug delivery and for interstitial fluid diagnostics , [ ] .

Techniques: Modification, Migration, Infection

Journal: Pharmaceutics

Article Title: Microneedles for Efficient and Precise Drug Delivery in Cancer Therapy

doi: 10.3390/pharmaceutics15030744

Figure Lengend Snippet: Summary of advantages and limitations of materials and fabrication methods used for different types of microneedles (solid, hollow, coated and dissolving).

Article Snippet: Nanoject ® ; Debiotech, Lausanne, Switzerland , Dissolvable peptide microneedle patch , Intradermal and hypodermic drug delivery and for interstitial fluid diagnostics , [ ] .

Techniques: Injection, Produced

Journal: Pharmaceutics

Article Title: Microneedles for Efficient and Precise Drug Delivery in Cancer Therapy

doi: 10.3390/pharmaceutics15030744

Figure Lengend Snippet: Comparisons among various routes of administrations (oral and hypodermal) commonly involved in conventional drug delivery methods with a transdermal microneedle system for cancer therapy (created using BioRender.com).

Article Snippet: Nanoject ® ; Debiotech, Lausanne, Switzerland , Dissolvable peptide microneedle patch , Intradermal and hypodermic drug delivery and for interstitial fluid diagnostics , [ ] .

Techniques:

Journal: Pharmaceutics

Article Title: Microneedles for Efficient and Precise Drug Delivery in Cancer Therapy

doi: 10.3390/pharmaceutics15030744

Figure Lengend Snippet: Summary of recent studies of microneedles on different cancer treatments.

Article Snippet: Nanoject ® ; Debiotech, Lausanne, Switzerland , Dissolvable peptide microneedle patch , Intradermal and hypodermic drug delivery and for interstitial fluid diagnostics , [ ] .

Techniques: In Vivo, Construct, Concentration Assay, Expressing, Produced

Journal: Pharmaceutics

Article Title: Microneedles for Efficient and Precise Drug Delivery in Cancer Therapy

doi: 10.3390/pharmaceutics15030744

Figure Lengend Snippet: Schematic illustration of smart microneedle system that consists of a loop system from diagnosis to cancer therapy (created using BioRender.com).

Article Snippet: Nanoject ® ; Debiotech, Lausanne, Switzerland , Dissolvable peptide microneedle patch , Intradermal and hypodermic drug delivery and for interstitial fluid diagnostics , [ ] .

Techniques: